Cell death machinery makes life more robust

نویسندگان

  • Cristina Aguirre-Chen
  • Christopher M Hammell
چکیده

CED-3, a protein that is essential for programmed cell death, also has an unexpected role in the regulation of non-apoptotic genes during normal development.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The impact of cellular characteristics on the evolution of shape homeostasis

The importance of individual cells in a developing multicellular organism is well known but precisely how the individual cellular characteristics of those cells collectively drive the emergence of robust, homeostatic structures is less well understood. For example cell communication via a diffusible factor allows for information to travel across large distances within the population, and cell p...

متن کامل

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.

Although autophagy controls cell death and survival, underlying mechanisms are poorly understood, and it is unknown whether autophagy affects only whether or not cells die or also controls other aspects of programmed cell death. MAP3K7 is a tumor suppressor gene associated with poor disease-free survival in prostate cancer. Here, we report that Map3k7 deletion in mouse prostate cells sensitizes...

متن کامل

Molecular mechanisms of irradiation-induced apoptosis.

The following review focuses on our current knowledge as to how the cell death regulatory machinery is activated to mediate irradiation-induced cell death. In particular, we will address recent developments related to the following questions: 1.) Which cell death regulatory genes mediate irradiation-induced cell death? 2.) What is the mechanism of irradiation-induced activation or suppression o...

متن کامل

MicroRNAs and the regulation of cell death.

Programmed cell death, or apoptosis, is ubiquitous, both during development and in the adult. Many components of the evolutionarily conserved machinery that brings about and regulates cell death have been identified, and all of these are proteins. However, in the past three years it has become clear that roughly 1% of predicted genes in animals encode small noncoding RNAs known as microRNAs, wh...

متن کامل

Critical Review Yeast Programmed Cell Death: An Intricate Puzzle

Yeasts as eukaryotic microorganisms with simple, well known and tractable genetics, have long been powerful model systems for studying complex biological phenomena such as the cell cycle or vesicle fusion. Until recently, yeast has been assumed as a cellular ‘clean room’ to study the interactions and the mechanisms of action of mammalian apoptotic regulators. However, the finding of an endogeno...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2014